Dendritic cells: not just another cell type in the kidney, but a complex immune sentinel network
- PMID: 16871253
- DOI: 10.1038/sj.ki.5001613
Dendritic cells: not just another cell type in the kidney, but a complex immune sentinel network
Abstract
Dendritic cells (DCs) are crucial for inducing and regulating adaptive immunity. These cells also exist in the kidney, where, however, their function had been unknown. A study by Soos et al. now demonstrates that renal DCs form an intricate cellular network that continuously surveys the tubulointerstitium, and reveals a previously unrecognized immune sentinel system of the kidney.
Comment on
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CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney.Kidney Int. 2006 Aug;70(3):591-6. doi: 10.1038/sj.ki.5001567. Epub 2006 Jun 7. Kidney Int. 2006. PMID: 16760907
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