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Review
. 2006 Jul-Aug;26(4-6):695-702.
doi: 10.1007/s10571-006-9041-0. Epub 2006 Jul 27.

Clinical catecholamine neurochemistry: a legacy of Julius Axelrod

David S Goldstein  1 , Graeme Eisenhofer, Irwin J Kopin
Affiliations
Review

Clinical catecholamine neurochemistry: a legacy of Julius Axelrod

David S Goldstein et al. Cell Mol Neurobiol. 2006 Jul-Aug.

Abstract

1. Discoveries, insights, and concepts that Julius Axelrod introduced about the disposition and metabolism of catecholamines provided the scientific basis and spurred the development of clinical catecholamine neurochemistry. 2. Here, we provide examples of this aspect of Axelrod's scientific legacy.

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Figures

Fig. 1.
Fig. 1.
Some chemical pathways of catecholamine synthesis and metabolism. Note the roles of catechol-O-methyltransferase (COMT) and phenylethanolamine-N-methyltransferase (PNMT), which Julius Axelrod discovered.
Fig. 2.
Fig. 2.
Sympathetic neuronal, extraneuronal, and adrenomedullary sources of catecholamines and some of their metabolites. Note the vesicular leakage and intracellular metabolism of catecholamines in sympathetic nerves and adrenomedullary cells, before the catecholamines enter the bloodstream.
See this image and copyright information in PMC

References

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