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. 2006 Summer;7(2):156-66.

Effect of phosphonoformic acid in the development of bovine embryos in vitro

Mylissa S D Marley  1 , M Daniel Givens, David A Stringfellow, Patricia K Galik, Kay P Riddell
Affiliations
  • PMID: 16871497

Effect of phosphonoformic acid in the development of bovine embryos in vitro

Mylissa S D Marley et al. Vet Ther. 2006 Summer.

Abstract

This research evaluated the ability of phosphonoformic acid to inhibit bovine herpesvirus 1 (BHV-1) in cumulus cells commonly used in co-culture with bovine in vitro-produced embryos. At 200 and 400 microg/ml, phosphonoformic acid inhibited 4 logs of BHV-1. Subsequently, phosphonoformic acid (200 and 400 microg/ml) added to both in vitro fertilization and culture medium resulted in a decrease in the proportion of developed blastocysts, and the number of cells per blastocyst was lower in the treated embryos. Therefore, while phosphonoformic acid can effectively inhibit replication of BHV-1 in co-culture cells, it also inhibits development of in vitro-produced bovine embryos.

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