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. 2006 Sep 15;16(18):4780-3.
doi: 10.1016/j.bmcl.2006.06.080. Epub 2006 Jul 25.

D609 blocks cell survival and induces apoptosis in neural stem cells

Nan Wang  1 , Xin Lv, Le Su, BaoXiang Zhao, ShangLi Zhang, JunYing Miao
Affiliations

D609 blocks cell survival and induces apoptosis in neural stem cells

Nan Wang et al. Bioorg Med Chem Lett. .

Abstract

In order to investigate the effects of tricyclodecane-9-yl-xanthogenate (D609) on the survival of neural stem cells (NSCs), which were isolated from rat forebrain, we treated the NSCs with D609 in the presence of basic fibroblast growth factor (bFGF). We found that when NSCs were exposed to 18.76-56.29 microM D609, the viability of the cells remarkably declined and apoptosis occurred. At the same time, the ROS level in NSCs was depressed. The data suggested that D609 was a powerful growth inhibitor and apoptosis inducer in NSCs.

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