Comment
doi: 10.1016/j.cell.2006.07.003.
MutLalpha: at the cutting edge of mismatch repair
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- PMID: 16873053
- DOI: 10.1016/j.cell.2006.07.003
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Comment
MutLalpha: at the cutting edge of mismatch repair
Cell.
.
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Abstract
The mismatch repair process corrects errors in newly synthesized DNA. In this issue, Modrich and colleagues (Kadyrov et al., 2006) show that a component of the human mismatch repair machinery, MutLalpha, has endonuclease activity. MutLalpha introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXOI to degrade the strand containing the mismatch.
Comment on
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Endonucleolytic function of MutLalpha in human mismatch repair.Cell. 2006 Jul 28;126(2):297-308. doi: 10.1016/j.cell.2006.05.039. Cell. 2006. PMID: 16873062
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