Comment
doi: 10.1016/j.cell.2006.07.008.
Blurring cis and trans in gene regulation
Affiliations
- PMID: 16873057
- DOI: 10.1016/j.cell.2006.07.008
Item in Clipboard
Comment
Blurring cis and trans in gene regulation
Cell.
.
Free article
Abstract
In this issue of Cell, Axel and colleagues (Lomvardas et al., 2006) report that a single enhancer of an odorant receptor (OR) gene cluster interacts with multiple OR gene promoters on different chromosomes. This study suggests a mechanism that allows olfactory sensory neurons to choose randomly and express only one out of more than 1000 OR genes.
Comment on
-
Interchromosomal interactions and olfactory receptor choice.Cell. 2006 Jul 28;126(2):403-13. doi: 10.1016/j.cell.2006.06.035. Cell. 2006. PMID: 16873069
Similar articles
-
Interchromosomal interactions and olfactory receptor choice.Cell. 2006 Jul 28;126(2):403-13. doi: 10.1016/j.cell.2006.06.035. Cell. 2006. PMID: 16873069
-
Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse.Science. 2003 Dec 19;302(5653):2088-94. doi: 10.1126/science.1089122. Epub 2003 Oct 30. Science. 2003. PMID: 14593185
-
Local and cis effects of the H element on expression of odorant receptor genes in mouse.Cell. 2007 Jul 27;130(2):373-84. doi: 10.1016/j.cell.2007.06.023. Cell. 2007. PMID: 17662950
-
Odorant receptor gene choice and axonal projection in the mouse olfactory system.Results Probl Cell Differ. 2009;47:57-75. doi: 10.1007/400_2008_3. Results Probl Cell Differ. 2009. PMID: 19083127 Review.
-
One neuron-one receptor rule in the mouse olfactory system.Trends Genet. 2004 Dec;20(12):648-53. doi: 10.1016/j.tig.2004.09.006. Trends Genet. 2004. PMID: 15522461 Review.
Cited by
-
High-throughput mapping of the promoters of the mouse olfactory receptor genes reveals a new type of mammalian promoter and provides insight into olfactory receptor gene regulation.Genome Res. 2011 Aug;21(8):1249-59. doi: 10.1101/gr.120162.110. Epub 2011 Jun 24. Genome Res. 2011. PMID: 21705439 Free PMC article.
-
Epigenetic principles and mechanisms underlying nervous system functions in health and disease.Prog Neurobiol. 2008 Dec 11;86(4):305-41. doi: 10.1016/j.pneurobio.2008.10.001. Epub 2008 Oct 17. Prog Neurobiol. 2008. PMID: 18940229 Free PMC article. Review.
-
Differentiation of developing olfactory neurons analysed in terms of coupled epigenetic landscapes.Nucleic Acids Res. 2013 May;41(9):4755-64. doi: 10.1093/nar/gkt181. Epub 2013 Mar 21. Nucleic Acids Res. 2013. PMID: 23519617 Free PMC article.
-
Non-Coding Variants in Cancer: Mechanistic Insights and Clinical Potential for Personalized Medicine.Noncoding RNA. 2021 Aug 2;7(3):47. doi: 10.3390/ncrna7030047. Noncoding RNA. 2021. PMID: 34449663 Free PMC article. Review.
-
A new insight into the impact of copy number variations on cell cycle deregulation of luminal-type breast cancer.Oncol Rev. 2025 Feb 12;19:1516409. doi: 10.3389/or.2025.1516409. eCollection 2025. Oncol Rev. 2025. PMID: 40017494 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
