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Review
. 2006 Jul 28;126(2):253-6.
doi: 10.1016/j.cell.2006.07.005.

FOXP3 and NFAT: partners in tolerance

Alexander Y Rudensky  1 , Marc Gavin, Ye Zheng
Affiliations
Free article
Review

FOXP3 and NFAT: partners in tolerance

Alexander Y Rudensky et al. Cell. .
Free article

Abstract

Regulatory T cells suppress autoimmune responses to self-antigens. Recent studies, including one in this issue of Cell (Wu et al., 2006), suggest that the ability of T cells to choose between launching a productive immune response, functional inactivation, or developing into regulatory T cells depends upon the interplay of the key transcriptional regulators FOXP3 and NFAT.

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