Review
doi: 10.1016/j.cell.2006.07.005.
FOXP3 and NFAT: partners in tolerance
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- PMID: 16873058
- DOI: 10.1016/j.cell.2006.07.005
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Review
FOXP3 and NFAT: partners in tolerance
Cell.
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Abstract
Regulatory T cells suppress autoimmune responses to self-antigens. Recent studies, including one in this issue of Cell (Wu et al., 2006), suggest that the ability of T cells to choose between launching a productive immune response, functional inactivation, or developing into regulatory T cells depends upon the interplay of the key transcriptional regulators FOXP3 and NFAT.
Comment on
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FOXP3 controls regulatory T cell function through cooperation with NFAT.Cell. 2006 Jul 28;126(2):375-87. doi: 10.1016/j.cell.2006.05.042. Cell. 2006. PMID: 16873067
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