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. 1991 Dec;35(12):2639-42.
doi: 10.1128/AAC.35.12.2639.

Inhibition of membrane potential-dependent amino acid transport by daptomycin

N E Allen  1 , W E Alborn Jr, J N Hobbs Jr
Affiliations

Inhibition of membrane potential-dependent amino acid transport by daptomycin

N E Allen et al. Antimicrob Agents Chemother. 1991 Dec.

Abstract

Daptomycin inhibits the formation of UDP-N-acetylmuramyl-pentapeptide in Bacillus megaterium by inhibiting active transport of amino acids incorporated into the pentapeptide. The ability of daptomycin to inhibit active transport and peptidoglycan formation may be due to its ability to disrupt the transmembrane electrochemical gradient.

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