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Case Reports
. 2006 Aug;25(8):749.
doi: 10.1097/01.inf.0000226941.85500.9b.

Nicolau syndrome after intramuscular benzathine penicillin treatment

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Case Reports

Nicolau syndrome after intramuscular benzathine penicillin treatment

Süheyla Ocak et al. Pediatr Infect Dis J. 2006 Aug.

Abstract

Nicolau syndrome (livedoid dermatitis) is a very rare complication of intramuscular injections and manifests as excruciating pain immediately after injection. We describe a 3-year-old boy with diagnosis of Nicolau syndrome after intramuscular benzathine penicillin injection to the midanterior part of the left thigh. He was treated with hyberbaric oxygen and pentoxyphilline in addition to supportive treatment and recovered with no sequelae.

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