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. 1977 Mar;81(3):681-5.
doi: 10.1093/oxfordjournals.jbchem.a131504.

A new enzyme, NADPH-dihydropteridine reductase in bovine liver

N Nakanishi, H Hasegawa, S Watabe
Free article

A new enzyme, NADPH-dihydropteridine reductase in bovine liver

N Nakanishi et al. J Biochem. 1977 Mar.
Free article

Abstract

An enzyme designated as NADPH-dihydropteridine reductase was found in the extract of bovine liver and partially purified. In contrast to NADH-dpendent dihydropteridine reductase [EC 1.6.99.7], the enzyme catalyzes the reduction of quinonid-dihydropterin to tetrahydropterin in the presence of NADPH. The two enzymes were separated by column chromatography on DEAE-sephadex. Tyrosine formation in the phenylalanine hydroxylation system was also stimulated by NADPH-dihydropteridine reductase. The existence of these two dihydropteridine reductases suggests that the tetrahydro from ofpteridine cofactor may be regenerated in two different ways in vivo.

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