doi: 10.1016/0742-8413(91)90029-s.
Cholinergic receptors and catecholamine secretion from adrenal chromaffin cells of the toad
Affiliations
- PMID: 1687546
- DOI: 10.1016/0742-8413(91)90029-s
Item in Clipboard
Cholinergic receptors and catecholamine secretion from adrenal chromaffin cells of the toad
Comp Biochem Physiol C Comp Pharmacol Toxicol.
1991.
Abstract
1. The effects of cholinergic drugs on catecholamine (CA) secretion from adrenal chromaffin tissue of the toad were studied. 2. CA secretion was induced by ACh or nicotine, but not by muscarine. 3. Hexamethonium inhibited the CA release evoked by ACh or nicotine, while d-tubocurarine only affected the nicotinic response. Atropine did not prevent the secretory response. 4. Muscarine abolished the secretion induced by the agonists, this effect being prevented by atropine or gallamine, but not by pirenzepine. 5. In conclusion, CA secretion in the toad is stimulated by activation of nicotinic receptors. Inhibitory muscarinic receptors are present, most likely of type M2, which may play a regulatory function.
Similar articles
-
Further evidence for nicotinic and muscarinic receptors and their interaction in dog adrenal medulla.Eur J Pharmacol. 1975 Dec;34(2):337-44. doi: 10.1016/0014-2999(75)90260-5. Eur J Pharmacol. 1975. PMID: 1234552
-
Mechanism of the differential effects of halothane on nicotinic- and muscarinic-receptor-mediated responses of the dog adrenal medulla.Anesthesiology. 1982 Dec;57(6):444-50. doi: 10.1097/00000542-198212000-00003. Anesthesiology. 1982. PMID: 7149302
-
Nicotinic and muscarinic components in acetylcholine stimulation of porcine adrenal medullary cells.Mol Cell Biochem. 1997 Apr;169(1-2):107-13. doi: 10.1023/a:1006867423715. Mol Cell Biochem. 1997. PMID: 9089637
-
Involvement of Ca2+ entry and inositol trisphosphate-induced internal Ca2+ mobilization in muscarinic receptor-mediated catecholamine release in dog adrenal chromaffin cells.Neurochem Int. 1992 Sep;21(2):259-67. doi: 10.1016/0197-0186(92)90156-l. Neurochem Int. 1992. PMID: 1363867
-
A single transmitter regulates gene expression through two separate mechanisms: cholinergic regulation of phenylethanolamine N-methyltransferase mRNA via nicotinic and muscarinic pathways.J Neurosci. 1994 Apr;14(4):2106-16. doi: 10.1523/JNEUROSCI.14-04-02106.1994. J Neurosci. 1994. PMID: 7512633 Free PMC article.
Cited by
-
Muscarinic Receptor Stimulation Does Not Inhibit Voltage-dependent Ca2+ Channels in Rat Adrenal Medullary Chromaffin Cells.Acta Histochem Cytochem. 2023 Aug 30;56(4):67-75. doi: 10.1267/ahc.23-00042. Epub 2023 Aug 23. Acta Histochem Cytochem. 2023. PMID: 37680574 Free PMC article.
-
Identification of muscarinic receptor subtypes involved in catecholamine secretion in adrenal medullary chromaffin cells by genetic deletion.Br J Pharmacol. 2015 Mar;172(5):1348-59. doi: 10.1111/bph.13011. Epub 2015 Jan 8. Br J Pharmacol. 2015. PMID: 25393049 Free PMC article.