Reduced serum levels of brain-derived neurotrophic factor in adult male patients with autism
- PMID: 16876305
- DOI: 10.1016/j.pnpbp.2006.06.018
Reduced serum levels of brain-derived neurotrophic factor in adult male patients with autism
Erratum in
- Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):592
Abstract
Background: The precise mechanisms underlying the pathophysiology of autism are currently unknown. Given the key role of brain-derived neurotrophic factor (BDNF) in brain development, we hypothesized that BDNF may play a role in the pathophysiology of autism. In this study, we studied whether serum levels of BDNF are altered in patients with autism.
Methods: We measured serum levels of BDNF in 18 adult male patients with autism and 18 age-matched healthy male control subjects.
Results: The serum levels of BDNF in patients with autism (25.6+/-2.15 ng/ml (mean+/-S.D.)) were significantly (z = -4.42, p < 0.001) lower than those of normal controls (61.6+/-10.9 ng/ml (mean+/-S.D.)). Nevertheless, we found no correlations between BDNF levels and clinical variables in autistic patients.
Conclusions: This study suggests that reduced BDNF levels may play a role in the pathophysiology of autism.
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