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. 2006 Sep 12;114(3):343-7.
doi: 10.1016/j.jconrel.2006.06.017. Epub 2006 Jun 23.

PEG-modified gold nanorods with a stealth character for in vivo applications

Takuro Niidome  1 , Masato Yamagata, Yuri Okamoto, Yasuyuki Akiyama, Hironobu Takahashi, Takahito Kawano, Yoshiki Katayama, Yasuro Niidome
Affiliations

PEG-modified gold nanorods with a stealth character for in vivo applications

Takuro Niidome et al. J Control Release. .

Abstract

Gold nanorods prepared in hexadecyltrimethylammonium bromide (CTAB) solution are expected to provide novel materials for photothermal therapy and photo-controlled drug delivery systems. Since gold nanorods stabilized with CTAB show strong cytotoxicity, we developed a technique to modify these with polyethyleneglycol (PEG) for medical applications. PEG-modification was achieved by adding mPEG-SH in the CTAB solution, then, excess CTAB was removed by dialysis. PEG-modified gold nanoparticles showed a nearly neutral surface, and had little cytotoxicity in vitro. Following intravenous injection into mice, 54% of injected PEG-modified gold nanoparticles were found in blood at 0.5 h after intravenous injection, whereas most of gold was detected in the liver in the case of original gold nanorods stabilized with CTAB.

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