Review
doi: 10.1080/03602530600727947.
Human ABC transporter ABCG2 in xenobiotic protection and redox biology
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- PMID: 16877258
- DOI: 10.1080/03602530600727947
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Review
Human ABC transporter ABCG2 in xenobiotic protection and redox biology
Drug Metab Rev.
2006.
Abstract
Human ATP-binding cassette (ABC) transporter ABCG2 (BCRP/MXR/ABCP) is regarded as a member of the phase III system of xenobiotic metabolism. This efflux pump is suggested to be responsible for protecting the body from toxic xenobiotics and for removing toxic metabolites. The aim of this review article is to address new aspects of ABCG2 related to redox biology, namely the posttranslational modification (intra- and intermolecular disulfide bond formation) of ABCG2 protein and the transport of porphyrin and chlorophyll metabolites, as well as the high-speed screening and QSAR analysis method to evaluate ABCG2-drug interactions.
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