Review
doi: 10.1093/bfgp/ell028.
Epub 2006 Jul 28.
Histone acetylation in gene regulation
Affiliations
- PMID: 16877467
- DOI: 10.1093/bfgp/ell028
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Review
Histone acetylation in gene regulation
Brief Funct Genomic Proteomic.
2006 Sep.
Abstract
Genetic information is packaged in the highly dynamic nucleoprotein structure called chromatin. Many biological processes are regulated via post-translational modifications of key proteins. Acetylation of lysine residues at the N-terminal histone tails is one of the most studied covalent modifications influencing gene regulation in eukaryotic cells. This review focuses on the role of enzymes involved in controlling both histone and non-histone proteins acetylation levels in the cell, with particular emphasis on their effects on cancer.
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