doi: 10.1007/978-3-7091-9175-0_16.
Stimulation of noradrenaline release in the cerebral cortex via presynaptic N-methyl-D-aspartate (NMDA) receptors and their pharmacological characterization
Affiliations
- PMID: 1687781
- DOI: 10.1007/978-3-7091-9175-0_16
Item in Clipboard
Stimulation of noradrenaline release in the cerebral cortex via presynaptic N-methyl-D-aspartate (NMDA) receptors and their pharmacological characterization
J Neural Transm Suppl.
1991.
Abstract
In rat brain cortex synaptosomes superfused with Mg(2+)-free solution containing glycine, [3H]noradrenaline (3H-NA) release evoked by NMDA was abolished by omission of glycine or Ca2+ and inhibited by Mg2+, the competitive and noncompetitive NMDA receptor antagonists CGP 37849 and dizocilpine (MK-801), respectively, as well as by ethanol, but was not affected by tetrodotoxin. The 3H-NA release evoked by L-glutamate was also competitively inhibited by CGP 37849. In conclusion, presynaptic NMDA receptors mediate stimulation of NA release. Ethanol probably acts at this receptor system.
Similar articles
-
Presynaptic site of action underlying the ethanol-induced inhibition of norepinephrine release evoked by stimulation of N-methyl-D-aspartate (NMDA) receptors in rat cerebral cortex.Brain Res. 1992 Feb 14;572(1-2):27-32. doi: 10.1016/0006-8993(92)90446-g. Brain Res. 1992. PMID: 1351786
-
Stimulation of noradrenaline release in human cerebral cortex mediated by N-methyl-D-aspartate (NMDA) and non-NMDA receptors.Br J Pharmacol. 1992 May;106(1):67-72. doi: 10.1111/j.1476-5381.1992.tb14294.x. Br J Pharmacol. 1992. PMID: 1380384 Free PMC article.
-
N-methyl-D-aspartate (NMDA) receptor-mediated stimulation of noradrenaline release, but not release of other neurotransmitters, in the rat brain cortex: receptor location, characterization and desensitization.Naunyn Schmiedebergs Arch Pharmacol. 1989 May;339(5):514-21. doi: 10.1007/BF00167254. Naunyn Schmiedebergs Arch Pharmacol. 1989. PMID: 2570360
-
Competitive antagonism of glycine at the N-methyl-D-aspartate (NMDA) receptor.Biochem Pharmacol. 1991 Jan 1;41(1):9-16. doi: 10.1016/0006-2952(91)90004-o. Biochem Pharmacol. 1991. PMID: 1824750 Review. No abstract available.
-
Presynaptic release-regulating NMDA receptors in isolated nerve terminals: A narrative review.Br J Pharmacol. 2021 Mar;178(5):1001-1017. doi: 10.1111/bph.15349. Epub 2021 Feb 2. Br J Pharmacol. 2021. PMID: 33347605 Free PMC article. Review.
Cited by
-
Stimulation of serotonin release in the rat brain cortex by activation of ionotropic glutamate receptors and its modulation via alpha 2-heteroreceptors.Naunyn Schmiedebergs Arch Pharmacol. 1995 Oct;352(4):394-401. doi: 10.1007/BF00172776. Naunyn Schmiedebergs Arch Pharmacol. 1995. PMID: 8532067
-
Modulation of N-methyl-D-aspartate (NMDA)-stimulated noradrenaline release in rat brain cortex by presynaptic alpha 2-adrenoceptors.Naunyn Schmiedebergs Arch Pharmacol. 1993 Oct;348(4):372-8. doi: 10.1007/BF00171336. Naunyn Schmiedebergs Arch Pharmacol. 1993. PMID: 7904051
-
Noradrenaline in the aging brain: Promoting cognitive reserve or accelerating Alzheimer's disease?Semin Cell Dev Biol. 2021 Aug;116:108-124. doi: 10.1016/j.semcdb.2021.05.013. Epub 2021 Jun 4. Semin Cell Dev Biol. 2021. PMID: 34099360 Free PMC article. Review.
-
Preferential location of N-methyl-D-aspartate (NMDA) receptors on postsynaptic membranes and on non-noradrenergic nerve terminals of the rat brain cortex.Naunyn Schmiedebergs Arch Pharmacol. 1992 Jun;345(6):633-8. doi: 10.1007/BF00164576. Naunyn Schmiedebergs Arch Pharmacol. 1992. PMID: 1386145
-
Norepinephrine ignites local hotspots of neuronal excitation: How arousal amplifies selectivity in perception and memory.Behav Brain Sci. 2016 Jan;39:e200. doi: 10.1017/S0140525X15000667. Epub 2015 Jul 1. Behav Brain Sci. 2016. PMID: 26126507 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Miscellaneous