Preliminary evidence for noradrenaline and ATP as neurotransmitters in the porcine isolated palmar common digital artery
- PMID: 1687785
- DOI: 10.1007/978-3-7091-9175-0_13
Preliminary evidence for noradrenaline and ATP as neurotransmitters in the porcine isolated palmar common digital artery
Abstract
Sympathetic neurotransmission in porcine isolated palmar common digital artery involves the release of noradrenaline and ATP which produce constrictor responses via alpha 1-adrenoceptor and P2x receptors, respectively. Responses to short trains of pulses (e.g. 4 pulses at 2Hz) are almost entirely attributable to ATP, while those to longer trains of pulses appear to involve both transmitters. Unlike the corresponding blood vessel in man (Stevens and Mould, 1985) no evidence for "innervated" post-junctional alpha 2-adrenoceptors was found.
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