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. 2006 Nov 15;14(22):7482-9.
doi: 10.1016/j.bmc.2006.07.015. Epub 2006 Aug 1.

Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety

Mari Sithambaram Karthikeyan  1 , Dasappa Jagadeesh Prasad, Boja Poojary, K Subrahmanya Bhat, Bantwal Shivarama Holla, Nalilu Suchetha Kumari
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Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety

Mari Sithambaram Karthikeyan et al. Bioorg Med Chem. .

Abstract

A series of 2,4-dichloro-5-fluorophenyl bearing Mannich base (4 and 5) was prepared from triazole Schiff bases (3) by aminomethylation with formaldehyde and secondary/substituted primary amines. All newly synthesized compounds were screened for their antimicrobial activity. Compounds 3c, 4c, 4e and 4f exhibited promising antibacterial and compounds 3c, 5c, 5e and 5f showed good antifungal activity.

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