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. 2006 Aug;33(8):1634-6.

Etanercept in adult patients with early onset ankylosing spondylitis

Robert D Inman  1 , Daniel O Clegg, John C Davis, James B Whitmore, Alan Solinger
Affiliations
  • PMID: 16881118

Etanercept in adult patients with early onset ankylosing spondylitis

Robert D Inman et al. J Rheumatol. 2006 Aug.

Abstract

Objective: To determine whether twice-weekly subcutaneous etanercept improves the signs and symptoms of adult patients with early onset ankylosing spondylitis (AS).

Methods: A retrospective analysis was performed on a subgroup of patients with AS with onset < 18 years of age from a multicenter, double-blind, placebo-controlled, randomized study of etanercept in the treatment of patients with AS. Twenty patients met criteria and are presented.

Results: As early as week four, 5/9 (56%) patients who received etanercept achieved an Assessments in Ankylosing Spondylitis 20% response (ASAS 20) versus only 1/11 (9%) of those who received placebo (p = 0.032). The observed ASAS 20 response continued through week 24, with 6/9 (66%) patients receiving etanercept responding, versus 2/11 of patients receiving placebo (p = 0.025).

Conclusion: Etanercept improves signs and symptoms of early onset AS in adult patients for at least 24 weeks.

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