Synthesis of homoallylic amines via the palladium-catalyzed decarboxylative coupling of amino acid derivatives
- PMID: 16881615
- DOI: 10.1021/ja063115x
Synthesis of homoallylic amines via the palladium-catalyzed decarboxylative coupling of amino acid derivatives
Abstract
Protected homoallylic amines are synthesized by the decarboxylative coupling of alpha-amino acid derivatives. The catalytic C-C bond-forming reaction relies on the bioinspired decarboxylative metalation of alpha-amino acids to produce alpha-amino anion equivalents. The alpha-amino anion equivalents are intercepted by pi-allyl palladium electrophiles to produce substituted homoallylic amines.
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