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. 2006 Aug 9;128(31):10002-3.
doi: 10.1021/ja063115x.

Synthesis of homoallylic amines via the palladium-catalyzed decarboxylative coupling of amino acid derivatives

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Synthesis of homoallylic amines via the palladium-catalyzed decarboxylative coupling of amino acid derivatives

Erin C Burger et al. J Am Chem Soc. .

Abstract

Protected homoallylic amines are synthesized by the decarboxylative coupling of alpha-amino acid derivatives. The catalytic C-C bond-forming reaction relies on the bioinspired decarboxylative metalation of alpha-amino acids to produce alpha-amino anion equivalents. The alpha-amino anion equivalents are intercepted by pi-allyl palladium electrophiles to produce substituted homoallylic amines.

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