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Review
. 2006 Oct;27(10):2523-33.
doi: 10.1016/j.peptides.2005.12.018. Epub 2006 Aug 1.

Bioactive analogs of neurotensin: focus on CNS effects

Mona Boules  1 , Paul Fredrickson, Elliott Richelson
Affiliations
Review

Bioactive analogs of neurotensin: focus on CNS effects

Mona Boules et al. Peptides. 2006 Oct.

Abstract

Neurotensin (NT) is a 13-amino acid neuropeptide found in the central nervous system and in the gastrointestinal tract. It is closely associated anatomically with dopaminergic and other neurotransmitter systems, and evidence supports a role for NT agonists in the treatment of various neuropsychiatric disorders. However, NT is readily degraded by peptidases, so there is much interest in the development of stable NT agonists, that can be injected systemically, cross the blood-brain barrier (BBB), yet retains the pharmacological characteristics of native NT for therapeutic use in the treatment of diseases such as schizophrenia, Parkinson's disease and addiction.

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