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. 2006 Aug;91(8):1117-20.

Clinical features and outcome of familial chronic lymphocytic leukemia

Francesca R Mauro  1 , Elena Giammartini, Massimo Gentile, Isabella Sperduti, Veronica Valle, Antonio Pizzuti, Anna Guarini, Diana Giannarelli, Robin Foà
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  • PMID: 16885053

Clinical features and outcome of familial chronic lymphocytic leukemia

Francesca R Mauro et al. Haematologica. 2006 Aug.

Abstract

The prognostic impact of the presence of a familial trait was analyzed in 1449 patient with chronic lymphocytic leukemia (CLL). A family history of hematologic malignancy (HM) was identified in 181 cases (12.5%) and recorded more frequently among female than male patients (HM: p < 0.05; CLL: p < 0.05). The relative was affected by CLL in 89 cases (6%). Familial and sporadic cases showed non-statistically different proportions of advanced stages (10.8 vs 7.1%) and patients requiring therapy (55 vs 60%) and a similar survival probability at 10 years (67 vs 66%). These data suggest that in CLL the presence of a familial trait does not imply an adverse prognosis.

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