Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Jan 1;171(1):345-9.
doi: 10.1084/jem.171.1.345.

An Epstein-Barr virus-specific cytotoxic T cell epitope in EBV nuclear antigen 3 (EBNA 3)

S R Burrows  1 , T B Sculley, I S Misko, C Schmidt, D J Moss
Affiliations

An Epstein-Barr virus-specific cytotoxic T cell epitope in EBV nuclear antigen 3 (EBNA 3)

S R Burrows et al. J Exp Med. .

Abstract

Epstein-Barr virus (EBV)-specific CTL clones were isolated that recognized A-type EBV transformants but not B-type transformants. These A-type-specific CTL clones (HLA B8 restricted) were used to screen peptides derived from the EBV nuclear antigens (EBNAs) 2, 3, 4, and 6 as potential CTL epitopes. Of the 76 peptides screened, one sequence from EBNA 3 (residues 329-353) was recognized by A-type-specific CTL clones after absorption onto target cells (either autologous B-type transformants or PHA blasts). This report is the first description of an EBV target epitope recognized by specific CTL clones.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Exp Med. 1988 Jun 1;167(6):1811-24 - PubMed
    1. Proc Natl Acad Sci U S A. 1987 Jul;84(13):4567-71 - PubMed
    1. J Gen Virol. 1987 Nov;68 ( Pt 11):2853-62 - PubMed
    1. Virology. 1989 Aug;171(2):401-8 - PubMed
    1. J Virol. 1989 Mar;63(3):1031-9 - PubMed