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. 2006 Sep 1;43(5):585-92.
doi: 10.1086/506350. Epub 2006 Jul 26.

The association of newly identified respiratory viruses with lower respiratory tract infections in Korean children, 2000-2005

Eun Hwa Choi  1 , Hoan Jong Lee, Sun Jung Kim, Byung Wook Eun, Nam Hee Kim, Jin A Lee, Jun Ho Lee, Eun Kyung Song, So Hee Kim, Ji Yong Park, Ji Yeon Sung
Affiliations

The association of newly identified respiratory viruses with lower respiratory tract infections in Korean children, 2000-2005

Eun Hwa Choi et al. Clin Infect Dis. .

Abstract

Background: This study was performed to evaluate the associations of newly recognized viruses, namely, human metapneumovirus (hMPV), human coronavirus (HCoV)-NL63, and human bocavirus (HBoV) with lower respiratory tract infections (LRTIs) in previously healthy children.

Methods: To determine the prevalences of 11 viruses--respiratory syncytial virus (RSV), adenovirus, rhinovirus, parainfluenza viruses (PIVs) 1 and 3, influenza viruses A and B, hMPV, HCoV, HCoV-NL63, and HBoV--among infants or children with LRTIs, in association with their epidemiologic characteristics, we performed multiplex reverse-transcriptase polymerase chain reaction on nasopharyngeal aspirates obtained from 515 children < or =5 years old with LRTIs during the period 2000-2005.

Results: Viruses were identified in 312 (60.6%) of the 515 patients. RSV was detected in 122 (23.7%), HBoV in 58 (11.3%), adenovirus in 35 (6.8%), PIV-3 in 32 (6.2%), rhinovirus in 30 (5.8%), hMPV in 24 (4.7%), influenza A in 24 (4.7%), PIV-1 in 9 (1.7%), influenza B in 9 (1.7%), and HCoV-NL63 in 8 (1.6%). Coinfections with > or =2 viruses were observed in 36 patients (11.5%). Twenty-two patients (37.9%) infected with HBoV had a coinfection. Bronchiolitis was frequently diagnosed in patients who tested positive for RSV, PIV-3, or rhinovirus, whereas influenza A, PIV-1, and HCoV-NL63 were commonly found in patients with croup. The age distributions of patients with viral infections differed; notably, RSV was responsible for 77% of LRTIs that occurred in infants < or =3 months old. The number of hMPV infections peaked between February and April, whereas the number of HCoV-NL63 infections peaked between April and May.

Conclusions: This study describes the features of LRTIs associated with newly identified viruses in children, compared with those associated with known viruses. Additional investigations are required to define the role of HBoV in LRTI.

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Figures

Table 1
Table 1
Primer sequences for multiplex RT-PCR.
Figure 1
Figure 1
Monthly occurrence of acute lower respiratory tract infections associated with 11 respiratory viruses isolated from children over the 5-year period 2000–2005.
Table 2
Table 2
Viruses identified in 515 nasopharyngeal aspirates obtained from previously healthy children with acute lower respiratory tract infections.
Table 3
Table 3
Comparison of the characteristics of the 265 children with acute lower respiratory tract infections with respect to the 8 major respiratory viruses.
Figure 2
Figure 2
Age distribution of children with lower respiratory tract infections associated with viral agents. The percentage of patients infected with individual viruses is shown for each age group. The sum of the proportion of persons infected with each virus in each of 4 age groups is 100%. aThe proportion of infants 3 months old; P < .04 for all comparisons between respiratory syncytial virus (RSV) and 6 viruses (adenovirus, bocavirus, parainfluenza virus [PIV]–3, influenza virus A, human metapneumovirus [hMPV], or human coronavirus [HCoV]–NL63; P < .03 for rhinovirus versus adenovirus or bocavirus, by Fisher's exact test. bComparison of the proportion of children >24 months old; P < .05 for RSV versus adenovirus, influenza A virus, bocavirus, or hMPV; P < .04 for rhinovirus versus adenovirus or bocavirus; and P < .03 for PIV-3 versus adenovirus or bocavirus, by Fisher's exact test.
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