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. 1975 Feb;146(2):497-9.
doi: 10.1042/bj1460497.

Subcellular localization of pulmonary antiotensin-converting enzyme (kininase II)

J W Ryan, U S Ryan, D R Schultz, C Whitaker, A Chung

Subcellular localization of pulmonary antiotensin-converting enzyme (kininase II)

J W Ryan et al. Biochem J. 1975 Feb.

Abstract

Goat antibodies to pig lung angiotensin-converting enzyme (kininase II) were conjugated to microperoxidase. Rat lung tissue, previously incubated with non-immune goat serum, was incubated with the antibody-microperoxidase conjugate and then with H2O2 and 3,3-diaminobenzidine. Electron microscopy revealed reaction product on the plasma membrane and caveolae of endothelial cells, especially those of capillaries and venules. These results support the hypothesis that angiotensin I and bradykinin are metabolized by enzymes on the luminal surface of pulmonary endothelial cells.

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