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. 2007 Mar;66(3):417-8.
doi: 10.1136/ard.2006.055012. Epub 2006 Aug 3.

The rate of NSAID-induced endoscopic ulcers increases linearly but not exponentially with age: a pooled analysis of 12 randomised trials

Maarten Boers  1 , Marco J D Tangelder, Hein van Ingen, John G Fort, Jay L Goldstein
Affiliations

The rate of NSAID-induced endoscopic ulcers increases linearly but not exponentially with age: a pooled analysis of 12 randomised trials

Maarten Boers et al. Ann Rheum Dis. 2007 Mar.

Abstract

The risk of major ulcer complications on treatment with non-steroidal anti-inflammatory drugs (NSAIDs) is known to increase exponentially with age. However, in a pooled analysis of 12 trial arms, the incidence of endoscopic ulcers on treatment with NSAID was found to increase with age in a roughly linear fashion. Thus, it is concluded that increasing age is associated with both more frequent and more serious NSAID gastropathy.

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Conflict of interest statement

Competing interests: MB has participated in advisory boards for Pharmacia and Pfizer, the manufacturer of celecoxib. MT, HI and JF were employees of Pharmacia at the time of design and execution of the study, but have left the company since its merger with Pfizer. JG has been reimbursed by Pharmacia and Pfizer for attending conferences, speaking/participating at conferences, and has received monies to conduct research and has also received compensation for acting as a consultant.

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