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. 1990 Jan 15;46(1):94-7.
doi: 10.1007/BF01955428.

Deficiency of kallikrein-like enzyme activities in cerebral tissue of patients with Alzheimer's disease

T Aoyagi  1 , T Wada, M Nagai, F Kojima, S Harada, T Takeuchi, H Takahashi, K Hirokawa, T Tsumita
Affiliations

Deficiency of kallikrein-like enzyme activities in cerebral tissue of patients with Alzheimer's disease

T Aoyagi et al. Experientia. .

Abstract

We examined the changes in the intracerebral activities, at the time of postmortem autopsy, in patients with Alzheimer's disease. When compared with the control group, the activity of kallikrein-like enzyme was significantly decreased, while prolyl endopeptidase activity increased, in the patients group. Aprotinin inhibited 50% of the activity of the former enzyme at 2 x 10(-7) M. Taken together with the results of a multivariate study, the above findings may indicate that intracerebral kallikrein deficiency plays an important role in the pathogenesis of Alzheimer's disease.

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References

    1. J Biochem. 1976 Oct;80(4):671-9 - PubMed
    1. J Biol Chem. 1980 Mar 25;255(6):2227-30 - PubMed
    1. Methods Enzymol. 1981;80 Pt C:535-61 - PubMed
    1. Biochem J. 1981 Jan 1;193(1):187-92 - PubMed
    1. J Biochem. 1973 Aug;74(2):247-52 - PubMed

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