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. 2006 Sep 8;313(5792):1438-41.
doi: 10.1126/science.1129577. Epub 2006 Aug 3.

Human IRGM induces autophagy to eliminate intracellular mycobacteria

Sudha B Singh  1 , Alexander S Davis, Gregory A Taylor, Vojo Deretic
Affiliations

Human IRGM induces autophagy to eliminate intracellular mycobacteria

Sudha B Singh et al. Science. .

Abstract

Immunity-related p47 guanosine triphosphatases (IRG) play a role in defense against intracellular pathogens. We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. We also identified a function for a human IRG protein in the control of intracellular pathogens and report that the human Irgm1 ortholog, IRGM, plays a role in autophagy and in the reduction of intracellular bacillary load.

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