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. 2006 Aug;135(2):243-7.
doi: 10.1016/j.otohns.2006.03.034.

DQA1 and DQB1 association and nasal polyposis

Germán Fajardo-Dolci  1 , Jesús Solorio-Abreu, Julio César Romero-Alvarez, Beatríz Zavaleta-Villa, Oscar Cerezo-Camacho, Rocío Jiménez-Lucio, Angélica Olivo-Díaz
Affiliations

DQA1 and DQB1 association and nasal polyposis

Germán Fajardo-Dolci et al. Otolaryngol Head Neck Surg. 2006 Aug.

Abstract

Objective: The aim of this study was to determine the contribution of the human major histocompatibility complex (HLA)-DQA1, -DQB1, and TNFalpha genes with simple nasal polyposis.

Study design and setting: A comparative case-control study with 31 patients and 151 controls was performed. HLA-DQA1, -DQB1, and TNFalpha -238 promoter position loci were typed by polymerase chain reaction (PCR) and sequence specific oligonucleotide probes (SSOPs). TNFalpha -308 promoter position was determined by PCR and digestion with NcoI restriction enzyme.

Results: The allele HLA-DQA1*0201 (P(c) = 0.019) had an etiologic fraction (EF) of 17%, whereas 13% EF was found for the haplotype HLA-DQA1*0201-DQB1*0201 (P = 0.016). Analysis of -DQB1 and TNFalpha promoter did not show significant differences between cases and controls.

Conclusions: HLA-DQA1*0201-DQB1*0201 haplotype is involved in susceptibility, conferring 5.53 times more risk of developing this disease.

Ebm rating: B-2b.

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