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. 2006 Aug;44(8):3021-4.
doi: 10.1128/JCM.02207-05.

False-positive results of enzyme immunoassays for human immunodeficiency virus in patients with uncomplicated malaria

Anne F Gasasira  1 , Grant Dorsey, Moses R Kamya, Diane Havlir, Moses Kiggundu, Philip J Rosenthal, Edwin D Charlebois
Affiliations

False-positive results of enzyme immunoassays for human immunodeficiency virus in patients with uncomplicated malaria

Anne F Gasasira et al. J Clin Microbiol. 2006 Aug.

Abstract

Malaria may impact upon human immunodeficiency virus (HIV) test results. We evaluated two HIV enzyme immunoassays (EIAs) by testing 1,965 Ugandans with malaria. We found poor positive predictive values (53% and 76%), particularly with younger age. Combining EIAs eliminated false positives but missed 21% of true positives. Performance of HIV EIAs in malaria may be unsatisfactory.

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Figures

FIG. 1.
FIG. 1.
Relationship between the probability of a false-positive HIV-1 EIA result and increasing age among subjects witha positive HIV-1 EIA test result, determined using locally weighted scatter plot smoothing (LOESS). A, rLAV test; B, Vironostika test.
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