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Comparative Study
. 2006 Aug 7;95(3):374-7.
doi: 10.1038/sj.bjc.6603281.

Cigarette smoking, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma

B A C van Dijk  1 , L J Schouten, E Oosterwijk, C A Hulsbergen-van de Kaa, L A L M Kiemeney, R A Goldbohm, J A Schalken, P A van den Brandt
Affiliations
Comparative Study

Cigarette smoking, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma

B A C van Dijk et al. Br J Cancer. .

Abstract

We investigated whether smoking is associated with mutations in the Von Hippel-Lindau (VHL) gene in 337 cases of sporadic renal cell carcinoma (RCC) among 120 852 people followed for 11.3 years; the findings suggest that smoking causes RCC independently of VHL gene mutations.

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References

    1. Brauch H, Weirich G, Hornauer MA, Storkel S, Wohl T, Bruning T (1999) Trichloroethylene exposure and specific somatic mutations in patients with renal cell carcinoma. J Natl Cancer Inst 91: 854–861 - PubMed
    1. Brauch H, Weirich G, Klein B, Rabstein S, Bolt HM, Bruning T (2004) VHL mutations in renal cell cancer: does occupational exposure to trichloroethylene make a difference? Toxicol Lett 151: 301–310, (doi:10.1016/j.toxlet.2003.12.074) - PubMed
    1. Gnarra JR, Duan DR, Weng Y, Humphrey JS, Chen DY, Lee S, Pause A, Dudley CF, Latif F, Kuzmin I, Schmidt L, Duh FM, Stackhouse T, Chen F, Kishida T, Wei MH, Lerman MI, Zbar B, Klausner RD, Linehan WM (1996) Molecular cloning of the von Hippel–Lindau tumour suppressor gene and its role in renal carcinoma. Biochim Biophys Acta 1242: 201–210 - PubMed
    1. Goldbohm RA, van den Brandt PA, Brants HA, van't Veer P, Al M, Sturmans F, Hermus RJ (1994a) Validation of a dietary questionnaire used in a large-scale prospective cohort study on diet and cancer. Eur J Clin Nutr 48: 253–265 - PubMed
    1. Goldbohm RA, Van den Brandt PA, Brants HA, Van't Veer P, Sturmans F, Hermus RJJ (1991) A self-administered questionnaire to assess dietary habits in a cohort study on diet and cancer. In The Diet History Method. Proceedings of the Second Berlin Meeting on Nutritional Epidemiology, Berlin, October 1989 Kohlmeier L (ed) pp 93–96. London: Smith-Gordon

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