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. 1990 Feb;84(3):244-8.
doi: 10.1007/BF00200568.

Nucleolus organizer regions in human lymphocytes as studied with premature chromosome condensation

F Wachtler  1 , C Roubicek, A Schedle, W Mosgöller, G Bretis, H G Schwarzacher
Affiliations

Nucleolus organizer regions in human lymphocytes as studied with premature chromosome condensation

F Wachtler et al. Hum Genet. 1990 Feb.

Abstract

Non-stimulated human lymphocytes from peripheral blood usually contain only one ring-shaped nucleolus. Polyethyleneglycol-mediated cell fusion with mitotic Chinese hamster ovary cells induces premature chromosome condensation in human lymphocytes. Subsequent silver staining reveals that more than one nucleolus organizer region (NOR) is silver-positive and frequently participates in the formation of "satellite associations". It can therefore be concluded that more than one NOR contributes to the ring-shaped nucleoli of lymphocytes in human peripheral blood and that they may be transcriptionally active. During phytohemagglutinin (PHA) stimulation, the number of silver-positive NORs, the number of nucleoli and the number of chromosomes participating in "satellite associations" increase.

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