doi: 10.1016/S0006-3495(90)82588-1.
Percolation model of ionic channel dynamics
Affiliations
- PMID: 1689594
- PMCID: PMC1280766
- DOI: 10.1016/S0006-3495(90)82588-1
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Percolation model of ionic channel dynamics
Biophys J.
1990 Mar.
Abstract
The nonexponential closed-time distributions observed for ionic channels have been explained recently by quasi-one-dimensional models of structural diffusion (Millhauser, G. L., E. E. Salpeter, and R. E. Oswald. 1988. Proc. Natl. Acad. Sci. USA. 85: 1503-1507; Condat, C. A., and J. Jäckle. 1989. Biophys. J. 55: 915-925; Levitt, D. G. 1989. Biophys. J. 55: 489-498). We generalize this treatment by allowing for more complex trajectories using percolation theory. We assume that the gating transition depends on marginally connected conformational states leading to the observed spread in time scales.
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