Increased subcutaneous and epicardial adipose tissue production of proinflammatory cytokines in cardiac surgery patients: possible role in postoperative insulin resistance
- PMID: 16895955
- DOI: 10.1210/jc.2006-1044
Increased subcutaneous and epicardial adipose tissue production of proinflammatory cytokines in cardiac surgery patients: possible role in postoperative insulin resistance
Abstract
Context: Hyperglycemia and insulin resistance frequently occur in critically ill patients even without a history of diabetes.
Objective: Our objective was to study the role of adipose tissue hormonal production in the development of insulin resistance in cardiac surgery patients. PARTICIPANTS, INTERVENTIONS, AND SETTINGS: Fifteen patients with elective cardiac surgery underwent blood sampling before, at the end, and 6, 12, 24, 48, and 120 h after the end of their operation. Epicardial and sc adipose tissue sampling was done at the beginning and at the end of surgery in the Department of Cardiac Surgery.
Main outcome measures: We measured serum concentrations and sc and epicardial adipose tissue mRNA expression of IL-6, monocyte chemoattractant protein-1 (MCP-1), TNF-alpha, leptin, resistin, and adiponectin and sc and epicardial adipose tissue mRNA expression of CD14, CD45, and CD68.
Results: The rate of insulin infusion required to maintain euglycemia increased up to 7-fold 12 h after the operation, suggesting the development of insulin resistance. Serum IL-6 levels increased 43-fold 12 h after surgery. MCP-1 peaked 6-fold at the end of surgery. Smaller peaks of TNF-alpha and leptin appeared 6 and 12 h after surgery, respectively. Resistin levels peaked 4-fold 24 h after surgery, but adiponectin levels were not significantly affected. TNF-alpha and CD45 mRNA expression increased markedly during the operation in sc adipose tissue. IL-6, resistin, and MCP-1 mRNA expression increased in both sc and epicardial adipose tissue. Leptin, adiponectin, CD14, and CD68 mRNA expression did not change significantly.
Conclusions: Both sc and epicardial adipose tissue is a source of proinflammatory cytokines in cardiac surgery patients and may contribute to the development of postoperative insulin resistance.
Similar articles
-
Increased production of proinflammatory cytokines in adipose tissue of patients with end-stage renal disease.Nutrition. 2009 Jul-Aug;25(7-8):762-8. doi: 10.1016/j.nut.2008.12.012. Nutrition. 2009. PMID: 19539174
-
Increased angiotensinogen production in epicardial adipose tissue during cardiac surgery: possible role in a postoperative insulin resistance.Physiol Res. 2008;57(6):911-917. doi: 10.33549/physiolres.931315. Epub 2007 Nov 30. Physiol Res. 2008. PMID: 18052686
-
Adipose proinflammatory cytokine expression through sympathetic system is associated with hyperglycemia and insulin resistance in a rat ischemic stroke model.Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E155-63. doi: 10.1152/ajpendo.00301.2010. Epub 2010 Oct 26. Am J Physiol Endocrinol Metab. 2011. PMID: 20978230
-
Recent advances in the relationship between obesity, inflammation, and insulin resistance.Eur Cytokine Netw. 2006 Mar;17(1):4-12. Eur Cytokine Netw. 2006. PMID: 16613757 Review.
-
Multihormonal control of ob gene expression and leptin secretion from cultured human visceral adipose tissue: increased responsiveness to glucocorticoids in obesity.J Clin Endocrinol Metab. 1998 Mar;83(3):902-10. doi: 10.1210/jcem.83.3.4644. J Clin Endocrinol Metab. 1998. PMID: 9506746 Review.
Cited by
-
Left atrial epicardial adipose tissue is closely associated with left atrial appendage flow velocity in patients with nonvalvular atrial fibrillation.Sci Rep. 2022 Jun 24;12(1):10742. doi: 10.1038/s41598-022-13988-3. Sci Rep. 2022. PMID: 35750694 Free PMC article.
-
Relationship Between Epicardial Adipose Tissue and Body Composition as Determined by Multi-Frequency Bioelectrical Impedance Analysis in Patients with Stage 5 Chronic Kidney Disease.Med Sci Monit. 2020 Feb 7;26:e920233. doi: 10.12659/MSM.920233. Med Sci Monit. 2020. PMID: 32029697 Free PMC article.
-
Pharmacy management of postoperative blood glucose in open heart surgery patients: evaluation of an intravenous to subcutaneous insulin protocol.Hosp Pharm. 2014 Feb;49(2):164-9. doi: 10.1310/hpj4902-164. Hosp Pharm. 2014. PMID: 24623869 Free PMC article.
-
Left ventricular hypertrophy and obesity: only a matter of fat?High Blood Press Cardiovasc Prev. 2015 Mar;22(1):29-41. doi: 10.1007/s40292-014-0068-x. Epub 2014 Aug 13. High Blood Press Cardiovasc Prev. 2015. PMID: 25117210 Review.
-
Transcriptome and Molecular Endocrinology Aspects of Epicardial Adipose Tissue in Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Observational Studies.Biomed Res Int. 2015;2015:926567. doi: 10.1155/2015/926567. Epub 2015 Nov 9. Biomed Res Int. 2015. PMID: 26636103 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous