Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Sep;7(9):644-56.
doi: 10.1038/nrm1988. Epub 2006 Aug 9.

The anaphase promoting complex/cyclosome: a machine designed to destroy

Jan-Michael Peters  1
Affiliations
Review

The anaphase promoting complex/cyclosome: a machine designed to destroy

Jan-Michael Peters. Nat Rev Mol Cell Biol. 2006 Sep.

Abstract

The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has essential functions in and outside the eukaryotic cell cycle. It is the most complex molecular machine that is known to catalyse ubiquitylation reactions, and it contains more than a dozen subunits that assemble into a large 1.5-MDa complex. Recent discoveries have revealed an unexpected multitude of mechanisms that control APC/C activity, and have provided a first insight into how this unusual ubiquitin ligase recognizes its substrates.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources