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. 2006 Aug;373(5):381-6.
doi: 10.1007/s00210-006-0086-x. Epub 2006 Aug 1.

Enhancement of vascular smooth muscle cell migration by urotensin II

Satoshi Matsusaka  1 , Ichiro Wakabayashi
Affiliations

Enhancement of vascular smooth muscle cell migration by urotensin II

Satoshi Matsusaka et al. Naunyn Schmiedebergs Arch Pharmacol. 2006 Aug.

Abstract

The effects of urotensin II (UII) on migration of human aortic smooth muscle cells (HASMCs) were investigated. UII (1-100 nM) significantly increased velocity of HASMC motility in a concentration-dependent manner. Stress-fiber formation and ERK (p44/p42) activity were also increased by UII. U0126 and PD 98059, MEK inhibitors, abolished the effects of UII on motility velocity and stress-fiber formation. These results suggest that UII enhances HASMC migration through activation of an ERK-dependent pathway.

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References

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