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Review
. 2006 Dec;30(6):445-51.
doi: 10.1007/s00264-006-0192-x. Epub 2006 Aug 3.

Current strategies of chemotherapy in osteosarcoma

Dorothe Carrle  1 , Stefan S Bielack
Affiliations
Review

Current strategies of chemotherapy in osteosarcoma

Dorothe Carrle et al. Int Orthop. 2006 Dec.

Abstract
in English, French

Osteosarcoma, the most common type of primary malignant tumour that develops in bone, can be classified into several different sub-types. While the majority of osteosarcomas are highly malignant, there are some low-grade variants. Since the introduction of chemotherapy into the multi-modal treatment regimen of high-grade osteosarcoma, its prognosis has impressively improved, with long-term survival being achieved in two-thirds of all patients. This review summarises current chemotherapeutic treatment strategies in classical osteosarcoma and also addresses the indication for chemotherapy in more unusual types and variants. It emphasises the need for treatment in specialised centres and within prospective, multi-institutional trials, amongst which EURAMOS1 and EURO-B.O.S.S are currently active in many European countries.

L’ostéosarcome est la tumeur osseuse la plus fréquente, cependant la plupart des ostéosarcomes ont une haute malignité, peu sont de malignité de bas de grade. Depuis l’utilisation de la chimio thérapie dans le traitement des ostéosarcomes de haute malignité, le pronostic a été très nettement amélioré, permettant une survie à long terme chez les deux tiers des patients. Cet article fait la revue des différentes stratégies thérapeutiques de chimiothérapie dans le traitement de l’ostéosarcome et de ses différents types. Il met en évidence que les traitements doivent être réalisés dans des centres spécialisés avec des études prospectives, multi sites, comme celles réalisées avec EURAMOS 1 et EURO-BOSS dans les pays européens.

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Figures

Fig. 1
Fig. 1
Histology of osteosarcoma before (a) and after (b) preoperative chemotherapy (good response)
Fig. 2
Fig. 2
Response to preoperative chemotherapy and survival. Grades 1 through 6 represent increasing tumour viability (reprinted from [3] with permission from the American Society of Clinical Oncology)
Fig. 3
Fig. 3
Outline of the chemotherapy regimens used in the current multi-centre trials EURAMOS1 (a) and EURO-B.O.S.S. (b). See text for details
See this image and copyright information in PMC

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    1. Ahmad SA, Patel SR, Ballo MT, Baker TP, Yasko AW, Wang X, Feig BW, Hunt KK, Lin PP, Weber KL, Chen LL, Zagars GK, Pollock RE, Benjamin RS, Pisters PW. Extraosseous osteosarcoma: response to treatment and long-term outcome. J Clin Oncol. 2002;20:521–527. doi: 10.1200/JCO.20.2.521. - DOI - PubMed
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