Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Jul;11(4):412-23.
doi: 10.1007/s00776-006-1037-6.

Premalignant conditions of bone

Andrew Horvai  1 , K Krishnan Unni
Affiliations
Review

Premalignant conditions of bone

Andrew Horvai et al. J Orthop Sci. 2006 Jul.
No abstract available

PubMed Disclaimer

Figures

Fig. 1A–D
Fig. 1A–D
Osteosarcoma arising in Paget’s disease. A Left ileum with expansile mass in a patient with Paget’s disease. B Area of Paget’s disease uninvolved by sarcoma. C, D Osteo- genic sarcoma corresponding to iliac lesion with abundant hyperchromatic, pleomorphic cells and lace-like osteoid
Fig. 2A–C
Fig. 2A–C
Squamous cell carcinoma arising in chronic osteomyelitis with a fistula tract. A Large, destructive lesion of the femur underneath a fistula tract noted on T1-weighted magnetic resonance imaging. B, C Squamous cell carcinoma shows diagnostic foci of keratinization and intercytoplasmic bridges
Fig. 3A–D
Fig. 3A–D
Chondrosarcoma arising in an osteochondroma. A Large, ill-defined soft tissue mass with ring-like calcifications arising at the site of prior osteochondroma in the humerus. B Gross pathology of chondrosarcoma arising from osteochondroma of the sacrum demonstrates irregular mineralization and cystic degeneration. C Loss of columnar architecture and thick cartilage cap (edge of cap is visible at top right) are common. D In a grade I chondrosarcoma cytology is typically bland
Fig. 4A–C
Fig. 4A–C
Chondrosarcoma arising in the setting of multiple enchondromas. A Plain radiograph from an Ollier disease patient demonstrating multiple enchondromas of the digits. B Computed tomography scan from an Ollier disease patient showing a large, destructive mass of the ileum. C Permeation of existing trabecular bone is diagnostic of chondrosarcoma
Fig. 5A–C
Fig. 5A–C
Chondrosarcoma in synovial chondromatosis. A The benign cartilage of synovial chondromatosis shows a lobular growth pattern at low power. B Synovial chondromatosis often demonstrates chondrocyte clustering, nuclear hyperchromasia, and binucleation and should not be mistaken for chondrosarcoma. C Plain radiograph of a patient with synovial chondromatosis and knee hemiarthroplasty with a new ill-defined soft tissue density adjacent to the knee joint. D Loss of clustering and spindling of chondrocytes at the periphery of a lobule are suggestive of chondrosarcoma in this setting
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Wang LL, Levy ML, Lewis RA, Chintagumpala MM, Lev D, Rogers M, et al. Clinical manifestations in a cohort of 41 Rothmund-Thomson syndrome patients. Am J Med Genet. 2001;102:11–7. doi: 10.1002/1096-8628(20010722)102:1<11::AID-AJMG1413>3.0.CO;2-A. - DOI - PubMed
    1. Hadjipavlou A, Lander P, Srolovitz H, Enker IP. Malignant transformation in Paget disease of bone. Cancer. 1992;70:2802–8. doi: 10.1002/1097-0142(19921215)70:12<2802::AID-CNCR2820701213>3.0.CO;2-N. - DOI - PubMed
    1. Greditzer HG, 3rd, McLeod RA, Unni KK, Beabout JW. Bone sarcomas in Paget disease. Radiology. 1983;146:327–33. - PubMed
    1. McKenna RJ, et al. Osteogenic sarcoma arising in Paget’s disease. Cancer. 1964;17:42–66. doi: 10.1002/1097-0142(196401)17:1<42::AID-CNCR2820170108>3.0.CO;2-U. - DOI - PubMed
    1. McKenna RJ, Schwinn CP, Soong KY, Higinbotham NL. Sarcomate of the osteogenic series (osteosarcoma, fibrosarcoma, chondrosarcoma, parosteal osteogenic sarcoma, and sarcomata arising in abnormal bone): an analysis of 552 cases. J Bone Joint Surg. 1966;48:1–26.

MeSH terms