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. 2006 Jun;23(6):261-7.
doi: 10.1007/s10815-006-9038-0. Epub 2006 Aug 1.

Subclinical pregnancy losses among women undergoing in-vitro fertilization with ICSI

Ulun Ulug  1 , Suleyman Tosun, Esra Aksoy Jozwiak, Ali Mesut, Alper Sismanoglu, Mustafa Bahceci
Affiliations

Subclinical pregnancy losses among women undergoing in-vitro fertilization with ICSI

Ulun Ulug et al. J Assist Reprod Genet. 2006 Jun.

Abstract

Background: The purpose of this study is to asses the frequency of subclinical pregnancy loss (SPL) among women undergoing controlled ovarian hyperstimulation (COH) and in-vitro fertilization with ICSI.

Methods: The study was retrospectively conducted in a private IVF center. SPL was defined by a temporary rise in serum beta hCG, along with the absence of signs of intra- and extra-uterine pregnancy by transvaginal ultrasonography. Overall 5273 COH and ICSI cycles with embryo transfer (ET) were segregated according to serum E(2) levels percentiles (-24th, 25th, 74th, and 75th), women age and the type of spermatozoa for assisted fertilization (ejaculated and surgically retrieved). Those groups were assessed for SPL rates.

Results: Among the 3125 (59.25) conception cycles, 305 (9.7%) were diagnosed as SPL. There was no difference in SPL rate among E(2) percentile groups. Women older than 35 years of age had significantly higher rate of SPL compared to younger women. There was also no difference in SPL rate among pregnancies in whom surgically retrieved spermatozoa used or ejaculated spermatozoa used for assisted fertilization.

Conclusion: Our results demonstrated that SPL rate was not influenced by the levels of E(2) during COH or the origin of spermatozoa used for assisted fertilization. However, maternal age was found to be detrimental for SPL.

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Figures

Fig. 1.
Fig. 1.
Subclinical pregnancy loss rates in groups of women by E2 percentile.
Fig. 2.
Fig. 2.
Subclinical pregnancy loss rates in groups of women by age.
Fig. 3.
Fig. 3.
Subclinical pregnancy loss rates according to origin of spermatozoa used for assisted fertilization.
See this image and copyright information in PMC

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