Functional roles of the gamma subunit of the skeletal muscle DHP-receptor

Abstract

In excitation-contraction coupling (EC coupling) of skeletal muscle, large and rapid changes of the myoplasmic Ca2+ concentration mediate the activation and termination of force. The L-type Ca2+ channel (dihydropyridine receptor, DHP receptor) is a central component of the EC coupling process. Its predominant role is to provide the Ca2+ release channels of the sarcoplasmic reticulum (SR) with the sensitivity to cell membrane voltage. The DHP receptor consists of five different proteins (alpha1S, beta1, gamma1, delta and alpha2) whose tasks and functional characteristics are still incompletely understood. This short review summarizes progress made in studying the physiology of the gamma1 subunit, a membrane polypeptide that is highly specific for skeletal muscle. The focus is on recent results obtained from muscle of gamma1-deficient mice.