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. 1990 Feb;22(1):52-6.

Pharmacokinetics of FK 506: preclinical and clinical studies

R Venkataramanan¹, A Jain, E Cadoff, V Warty, K Iwasaki, K Nagase, A Krajack, O Imventarza, S Todo, J J Fung, et al.

Affiliations

PMID: 1689899
PMCID: PMC2903896

Pharmacokinetics of FK 506: preclinical and clinical studies

R Venkataramanan et al. Transplant Proc. 1990 Feb.

. 1990 Feb;22(1):52-6.

Authors

R Venkataramanan¹, A Jain, E Cadoff, V Warty, K Iwasaki, K Nagase, A Krajack, O Imventarza, S Todo, J J Fung, et al.

Affiliation

¹ School of Pharmacy, University of Pittsburgh, PA 15261.

PMID: 1689899
PMCID: PMC2903896

No abstract available

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Figures

Fig 1 — Fig 1
Plasma concentration versus time profile after intravenous administration of FK 506 (0.2 mg/kg) to dogs.

Fig 2 — Fig 2
Tissue concentrations of FK 506 in rats after 14 days of intramuscular treatment (1.28 mg/kg/d).

Fig 3 — Fig 3
Percent of the dose excreted in urine, feces, and bile within 48 hours after intravenous and oral administration to bile duct cannulated rats.

Fig 4 — Fig 4
Plasma concentration of FK 506 versus time curve after intravenous infusion (9 mg over 2 hours) in two patients.

Fig 5 — Fig 5
Plasma concentration of FK 506 versus time curve after oral administration of 9 mg of FK 506 to four patients.

Fig 6 — Fig 6
Temperature-dependent plasma FK 506 concentration in patients. □, Blood sample separated at 24°C; , blood sample separated at 37°C.

formula image — Fig 6
Temperature-dependent plasma FK 506 concentration in patients. □, Blood sample separated at 24°C; , blood sample separated at 37°C.

See this image and copyright information in PMC

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References

1. Zeevi A, Duquesnoy R, Eiras G, et al. Transplant Proc. 1988;20:40. - PMC - PubMed
1. Starzl TE, Makowka L, Todo S. FK: A Potential Breakthrough in Immunosuppression. Grune & Stratum; Philadelphia, PA: 1987.
1. Honbo T, Kobayashi M, Hane K, et al. Transplant Proc. 1988;20:17. - PubMed
1. Cadoff E, Venkataramanan R, Krajack A, et al. Transplant Proc (this issue)
1. Venkataramanan R, Warty VS, Zemaitis MA, et al. Transplant Proc. 1988;20:30. - PMC - PubMed

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