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Review
. 2006 Sep;6(5):377-83.
doi: 10.1007/s11882-996-0007-6.

Mannan-binding lectin in asthma and allergy

Savneet Kaur  1 , Steffen Thiel, P Usha Sarma, Taruna Madan
Affiliations
Review

Mannan-binding lectin in asthma and allergy

Savneet Kaur et al. Curr Allergy Asthma Rep. 2006 Sep.

Abstract

Mannan-binding lectin (MBL) is a vital and versatile component of innate immunity. It is present in serum and may bind to a plethora of microbial pathogens and mediate opsonization of these by complement-dependent and/or independent mechanisms. Low-MBL levels in serum, attributed to certain genetic polymorphisms, constitute a major factor predisposing to several infectious diseases. However, recent studies propose that MBL extends beyond its classic role as a first-line host-defense molecule to a modulator of inflammation. In this review, we summarize and explore this potential and a possible novel role of MBL in asthma and allergy.

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