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. 2007 Apr 8;248(1):123-30.
doi: 10.1016/j.canlet.2006.06.009. Epub 2006 Aug 8.

Selective radiosensitization by nitric oxide in tumor cell lines

Lucía Policastro  1 , Hebe Duran, Yann Henry, Beatriz Molinari, Vincent Favaudon
Affiliations

Selective radiosensitization by nitric oxide in tumor cell lines

Lucía Policastro et al. Cancer Lett. .

Abstract

The radiosensitizing effect of nitric oxide (NO) on mouse and human tumor cells with different degrees of malignancy was evaluated. Cells pre-treated with the NO donor diethylenetriamine-NO (DETA-NO), were irradiated with gamma rays. Survival curves were obtained by clonogenicity and fitted to the linear-quadratic model. Results demonstrated an association between radiosensitization and degree of malignancy. The more malignant the cell line, the higher the degree of radiosensitization by DETA-NO. In conclusion, the differential radiosensitizing effect of DETA-NO shown here is of great interest for the potential use of NO in radiotherapy, due to an enhanced radiation effect on tumor vs. normal tissue.

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