Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Aug;24(8):942-6.
doi: 10.1038/nbt0806-942.

Shifting emphasis from pharmacogenomics to theragnostics

Vural Ozdemir  1 , Bryn Williams-Jones, Stephen J Glatt, Ming T Tsuang, James B Lohr, Christopher Reist
Affiliations
Review

Shifting emphasis from pharmacogenomics to theragnostics

Vural Ozdemir et al. Nat Biotechnol. 2006 Aug.

Abstract

What will be the role of theragnostic patents in upstream and downstream biomarker research?

PubMed Disclaimer

Figures

Figure 1
Figure 1. Hierarchy of biomarkers and their integration into theragnostic tests, from gene sequence (upstream or static marker) to downstream (dynamic) markers on gene and protein expression or cellular metabolites.
A theragnostic profile is depicted as a synthesis of various biomarker tests that characterize an individual patient and her/his drug treatment outcome. The theragnostic profile may be heuristic in nature when only a singular biomarker is associated with treatment outcomes while more mechanistic insights can be achieved when biomarkers from different levels of the biological hierarchy corroborate and complement each other.
See this image and copyright information in PMC

References

    1. Brown N. Science Studies. 2003;16:3–21.
    1. Hedgecoe AM. Science Technol. Human Values. 2003;28:513–537. doi: 10.1177/0162243903256274. - DOI
    1. Hedgecoe A, Martin P. Soc. Stud. Sci. 2003;33:327–364. doi: 10.1177/03063127030333002. - DOI - PubMed
    1. Williams-Jones B, Corrigan OP. Am. J. Pharmacogenomics. 2003;3:375–383. doi: 10.2165/00129785-200303060-00004. - DOI - PubMed
    1. Nightingale P, Martin P. Trends Biotechnol. 2004;22:564–569. doi: 10.1016/j.tibtech.2004.09.010. - DOI - PubMed

Publication types