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Controlled Clinical Trial
. 2006 Nov;70(11):1919-22.
doi: 10.1016/j.ijporl.2006.06.019. Epub 2006 Aug 9.

Effect of 1-deamino 8-D-arginine vasopressin spray on nasal cytology and mucociliary clearance in patients with nocturnal enuresis

Ertap Akoğlu  1 , Sadik Görür, Esin Atik, Semsettin Okuyucu, Ozlem Sangün
Affiliations
Controlled Clinical Trial

Effect of 1-deamino 8-D-arginine vasopressin spray on nasal cytology and mucociliary clearance in patients with nocturnal enuresis

Ertap Akoğlu et al. Int J Pediatr Otorhinolaryngol. 2006 Nov.

Abstract

Objective: To determine any possible adverse effect of 1-deamino 8-D-arginine vasopressin (DDAVP) spray on nasal cytology and mucociliary clearance in patients with nocturnal enuresis.

Methods: Twenty-two children aged 6-16 enrolled in the study. Epithelial surface cells samples were taken from the nasal mucosa and mucociliary clearance time was calculated before and 1 and 6 months after administration of DDAVP spray.

Results: No qualitative changes in the epithelial surface cells and mucociliary clearance time were observed at 1 and 6 months after therapy.

Conclusion: Based on the findings of the present study, DDAVP spray can be used for 6 months in children without apparent risk of damage to the epithelial surface cells and mucociliary clearance time.

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