doi: 10.1093/molbev/msl086.
Epub 2006 Aug 10.
Systematically assessing the influence of 3-dimensional structural context on the molecular evolution of mammalian proteomes
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- PMID: 16901983
- DOI: 10.1093/molbev/msl086
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Systematically assessing the influence of 3-dimensional structural context on the molecular evolution of mammalian proteomes
Mol Biol Evol.
2006 Nov.
Abstract
The 3-dimensional (3D) structural context of amino acid residues in a protein could significantly impact the level of selective constraint on the residues. Here, by analyzing 767 mammalian proteins, we systematically investigate how various 3D structural contexts influence selective constraint. The structural contexts we examined include solvent accessibility, secondary structure, and intramolecular residue-residue interactions. Through this analysis, we offer quantitative information on how 3D structural contexts affect the level of selective constraint.
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