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. 2006 Aug 11;313(5788):842-5.
doi: 10.1126/science.1128436.

Dodeca-CLE peptides as suppressors of plant stem cell differentiation

Yasuko Ito  1 , Ikuko Nakanomyo, Hiroyasu Motose, Kuninori Iwamoto, Shinichiro Sawa, Naoshi Dohmae, Hiroo Fukuda
Affiliations

Dodeca-CLE peptides as suppressors of plant stem cell differentiation

Yasuko Ito et al. Science. .

Abstract

In plants and animals, small peptide ligands that signal in cell-cell communication have been suggested to be a crucial component of development. A bioassay of single-cell transdifferentation demonstrates that a dodecapeptide with two hydroxyproline residues is the functional product of genes from the CLE family, which includes CLAVATA3 in Arabidopsis. The dodecapeptide suppresses xylem cell development at a concentration of 10(-11) M and promotes cell division. An application, corresponding to all 26 Arabidopsis CLE protein family members, of synthetic dodecapeptides reveals two counteracting signaling pathways involved in stem cell fate.

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