Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Aug;48(8):771-9.
doi: 10.1097/01.jom.0000233380.13087.37.

Community exposure to perfluorooctanoate: relationships between serum levels and certain health parameters

Edward Anthony Emmett  1 , Hong Zhang, Frances Susan Shofer, David Freeman, Nancy Virginia Rodway, Chintan Desai, Leslie Michael Shaw
Affiliations

Community exposure to perfluorooctanoate: relationships between serum levels and certain health parameters

Edward Anthony Emmett et al. J Occup Environ Med. 2006 Aug.

Abstract

Objective: The objective of this study was to determine whether certain biomarkers of toxicity and/or a past diagnosis of liver or thyroid disease were associated with serum perfluorooctanoate concentrations (PFOA) in a community with longstanding environmental exposure to PFOA.

Methods: Serum (PFOA), hematologic and biochemical biomarkers, and a questionnaire were administered to 371 residents selected by stratified random sampling and a lottery among volunteers. Median PFOA was 354 ng/mL (interquartile range, 181-571 ng/mL).

Results: No significant positive relationships between serum (PFOA) and liver or renal function tests, cholesterol, thyroid-stimulating hormone, or with red cell indices, white cell, or platelet counts. Mean serum (PFOA) was not increased in those with a history of liver or thyroid disease.

Conclusions: No toxicity from PFOA was demonstrated using the measured end points; other end points need to be addressed.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Frequency distribution of serum [PFOA] in the studied population of residents of the Little Hocking water service district. N = 371
See this image and copyright information in PMC

References

    1. Kennedy GL, Butenhoff JL, Olsen GW, et al. The toxicology of perfluorooctanoate. Crit Rev Tox. 2004;34:351–384. - PubMed
    1. Powley CR, Michalcyzyk MJ, Kaiser MA, et al. Determination of perfluorooctanoic acid (PFOA) extractable from the surface of commercial cookware under simulated cooking conditions by LC/MS/MS. Analyst. 2005;130:1299–1302. - PubMed
    1. Gribble GW. Naturally occurring organofluorines. In: Neilson AH, editor. The Handbook of Environmental Chemistry. Volume 3N. Berlin: Springer-Verlag; 2002. pp. 121–136.
    1. Kannan K, Koistinen J, Beckman K, et al. Accumulation of perfluorooctane sulfonate in marine mammals. Environ Sci Technol. 2001;35:1593–1598. - PubMed
    1. Olsen GW, Church TR, Miller JP, et al. Perfluorooctanesulfonate and other fluorochemicals in the serum of American Red Cross adult blood donors. Environ Health Perspect. 2003;111:1892–1901. - PMC - PubMed

Publication types

MeSH terms