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Review
. 2006 Sep;3(9):e351.
doi: 10.1371/journal.pmed.0030351.

Which topical microbicides for blocking HIV-1 transmission will work in the real world?

Per Johan Klasse  1 , Robin J Shattock, John P Moore
Affiliations
Review

Which topical microbicides for blocking HIV-1 transmission will work in the real world?

Per Johan Klasse et al. PLoS Med. 2006 Sep.

Abstract

Klasse and colleagues discuss key research on the four crucial issues in developing a microbicide: safety, acceptability, efficacy, and affordability.

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Conflict of interest statement

Competing interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. The HIV/SHIV Viral Load in Two Different Transmission Situations: Human Semen and the Inoculum in the Macaque Model For a detailed explanation of Figure 1, see Text S1.
Figure 2
Figure 2. Comparison of the Concentrations of Microbicide Compounds Required for Blocking Infection In Vitro and In Vivo For a detailed explanation of Figure 2, see Text S2.
Figure 3
Figure 3. Microbicidal Protection by Engineered Commensal Bacteria For a detailed explanation of Figure 3A, see Text S3. For a detailed explanation of Figure 3B, see Text S4.
See this image and copyright information in PMC

References

    1. Stone A. Microbicides: A new approach to preventing HIV and other sexually transmitted infections. Nat Rev Drug Discov. 2002;1:977–985. - PubMed
    1. Dhawan D, Mayer KH. Microbicides to prevent HIV transmission: Overcoming obstacles to chemical barrier protection. J Infect Dis. 2006;193:36–44. - PubMed
    1. Lederman MM, Offord RE, Hartley O. Microbicides and other topical strategies to prevent vaginal transmission of HIV. Nat Rev Immunol. 2006;6:371–382. - PubMed
    1. Weber JN, Lacey CJ. The development of novel vaginal microbicides: From the bench to the clinic. AIDS. 2001;15:S35–S37. - PubMed
    1. Shattock RJ, Moore JP. Inhibiting sexual transmission of HIV-1 infection. Nat Rev Microbiol. 2003;1:25–34. - PubMed

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