Housekeeping by Leishmania
- PMID: 16905359
- PMCID: PMC2679205
- DOI: 10.1016/j.pt.2006.08.003
Housekeeping by Leishmania
Abstract
The observation that differentiation of parasite life cycle stages involves structural and functional reorganisation is very familiar. A recent paper by Besteiro and colleagues provides an intriguing insight into cellular remodelling during differentiation. They show that it is essential for Leishmania to tidy up and put the house in order before it can differentiate to mammal-infective stages.
Comment on
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Endosome sorting and autophagy are essential for differentiation and virulence of Leishmania major.J Biol Chem. 2006 Apr 21;281(16):11384-96. doi: 10.1074/jbc.M512307200. Epub 2006 Feb 23. J Biol Chem. 2006. PMID: 16497676
References
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- Besteiro S. Endosome sorting and autophagy are essential for differentiation and virulence of Leishmania major. J. Biol. Chem. 2006;281:11384–11396. - PubMed
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- Rogers M.E. The role of promastigote secretory gel in the origin and transmission of the infective stage of Leishmania mexicana by the sandfly Lutzomyia longipalpis. Parasitology. 2002;124:495–508. - PubMed
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- Zakai H. In vitro stimulation of metacyclogenesis in Leishmania braziliensis, L. donovani. L. major and L. mexicana. Parasitology. 1998;116:305–309. - PubMed
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