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Review
. 2006 Oct;22(10):447-8.
doi: 10.1016/j.pt.2006.08.003. Epub 2006 Aug 14.

Housekeeping by Leishmania

Affiliations
Review

Housekeeping by Leishmania

Paul A Bates. Trends Parasitol. 2006 Oct.

Abstract

The observation that differentiation of parasite life cycle stages involves structural and functional reorganisation is very familiar. A recent paper by Besteiro and colleagues provides an intriguing insight into cellular remodelling during differentiation. They show that it is essential for Leishmania to tidy up and put the house in order before it can differentiate to mammal-infective stages.

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References

    1. Besteiro S. Endosome sorting and autophagy are essential for differentiation and virulence of Leishmania major. J. Biol. Chem. 2006;281:11384–11396. - PubMed
    1. Gossage S.M. Two separate growth phases during the development of Leishmania in sand flies: implications for understanding the life cycle. Int. J. Parasitol. 2003;33:1027–1034. - PMC - PubMed
    1. Rogers M.E. Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG. Nature. 2004;430:463–467. - PMC - PubMed
    1. Rogers M.E. The role of promastigote secretory gel in the origin and transmission of the infective stage of Leishmania mexicana by the sandfly Lutzomyia longipalpis. Parasitology. 2002;124:495–508. - PubMed
    1. Zakai H. In vitro stimulation of metacyclogenesis in Leishmania braziliensis, L. donovani. L. major and L. mexicana. Parasitology. 1998;116:305–309. - PubMed

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